Pulmonary infarction without fat or thrombo-embolism in sickle cell anaemia

Pulmonary platelet thrombo-embolism.

was demonstrated radiologically. Apart from a symptomless mitral stenosis, examination revealed no other abnormality. Nine years previously a right radical mastectomy had been performed for a scirrhous carcinoma; the axillary lymph nodes were tumour-free and a careful follow-up did not show evidence of either local or distant recurrence. At the time of admission the blood picture was as follows...

Pulmonary Platelet Thrombo-embolism

was demonstrated radiologically. Apart from a symptomless mitral stenosis, examination revealed no other abnormality. Nine years previously a right radical mastectomy had been performed for a scirrhous carcinoma; the axillary lymph nodes were tumour-free and a careful follow-up did not show evidence of either local or distant recurrence. At the time of admission the blood picture was as follows...

Fat embolism in sickle cell disease.

Fat embolism is a known complication of marrow infarction in patients with sickle cell disease (Hb S/S and Hb S/C) disease. It should be considered in sickle cell crisis when there is deterioration in respiratory function, a fall in arterial PO(2), a normoblastaemia, and a thrombocytopenia in the peripheral blood. We now report a patient in whom the diagnosis was confirmed in life by identifyin...

Pulmonary fat embolism: a distinct cause of severe acute chest syndrome in sickle cell anemia.

The etiology of most cases of acute chest syndrome (ACS) in sickle cell disease (SCD) is unknown. Although pulmonary fat embolism (PFE) is frequently found on autopsy, it is rarely considered in the differential diagnosis in pediatric patients. We conducted a study to determine if we could identify PFE in SCD patients with ACS, define the clinical and laboratory course of PFE, and determine if ...

Thrombo-embolism in acute and in healed myocardial infarction. II. Systemic and pulmonary arterial occlusion.